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S
| Language name | Native name | Code |
|---|---|---|
| Salishan languages | - | SAL |
| Samaritan Aramaic | ארמית, ܐܪܡܝܐ | SAM |
| Sami languages | - | SMI |
| Samoan | Gagana Fa'a Samoa | SMO |
| Sandawe | - | SAD |
| Sango | Yângâ Tî Sängö | SAG |
| Sanskrit | संस्कृतम् | SAN |
| Santali | संथाली | SAT |
| Sardinian | Sardu | SRD |
| Sasak | - | SAS |
| Scots | Scots Leid, Lallans | SCO |
| Selkup | Шӧльӄумыт Әты | SEL |
| Semitic languages | - | SEM |
| Serbian | Српски Језик, Srpski Jezik | SRP |
| Serer | - | SRR |
| Shan | - | SHN |
| Shona | Chishona | SNA |
| Sichuan Yi; Nuosu | ꆇꉙ | III |
| Sicilian | Sicilianu | SCN |
| Sidamo | Sidámo 'afó | SID |
| Sign Languages | - | SGN |
| Siksika | Siksiká, ᓱᖽᐧᖿ | BLA |
| Sindhi | سنڌي، سندھی, सिन्धी | SND |
| Sinhala; Sinhalese | සිංහල | SIN |
| Sino-Tibetan languages | - | SIT |
| Siouan languages | - | SIO |
| Skolt Sami | Sääʼmǩiõll | SMS |
| Slave | - | DEN |
| Slavic languages | - | SLA |
| Slovak | Slovenčina | SLO |
| Slovenian | Slovenščina | SLV |
| Sogdian | - | SOG |
| Somali | Soomaaliga, Af Soomaali | SOM |
| Songhai languages | - | SON |
| Soninke | Soninkanxaane | SNK |
| Sorbian languages | - | WEN |
| Sotho, Southern | Sesotho | SOT |
| South American Indian languages | - | SAI |
| Southern Altai | Алтай Тили | ALT |
| Southern Sami | Saemien Giele | SMA |
| Spanish; Castilian | Español, Castellano | SPA |
| Sranan Tongo | - | SRN |
| Sukuma | - | SUK |
| Sumerian | Eme-Ĝir | SUX |
| Sundanese | Basa Sunda | SUN |
| Susu | - | SUS |
| Swahili | Kiswahili | SWA |
| Swati | Siswati | SSW |
| Swedish | Svenska | SWE |
| Swiss German; Alemannic; Alsatian | Schwyzerdütsch, Alemannisch | GSW |
| Syriac | ܣܘܪܝܝܐ | SYR |